Having as theoretical background an analysis of changes in the definition of the museum and cultural heritage, the transformations in the way we preserve the memory of the past, and the ‘experiential and sensory turn’ in displays, the course turns attention to the new potentials offered by digital technologies to mediate between museum content and visitors. It aims to contribute to the understanding of the way their use interacts with the architectural and spatial design of museums/heritage sites. Particular emphasis is given to the creation of digital environments in different types of museums, from art and music museums to museums of sites and city museums, as well as historic monuments and heritage sites, and their role as interpretative media, and increasingly, as the exhibits and the key experiences themselves, which set challenges for curators, architects, designers. In parallel, the course provides students with practical skills and knowledge on issues of video processing, audio mixing, and visual effects. In the framework of the course, we analyze case studies of digital applications in Greek and foreign museums and heritage sites, we explain strategic design choices, in conjunction with specific aims and uses, and apply the acquired theoretical and practical knowledge to creating and presenting an audiovisual work supporting museum interpretation and experience.